![]() ![]() MCI has been defined as a broad concept however, the concept defined by Petersen has been presented as a standard ( 5). A proper screening tool is important as 6–15% of MCI cases convert to dementia each year, and early diagnosis can modify the conversion predictors and allow patients and families to improve or maintain their quality of life ( 2– 4). MCI is defined as the pre-dementia stage, in which cognitive impairment has not yet caused major problems in one’s daily function ( 1). There is a growing interest in the diagnosis of mild cognitive impairment (MCI) and early intervention for the prevention of conversion to dementia. It has also been shown that salivary DHEA can be used as a biomarker for MCI.Īs the older adult population has increased, the burden of cognitive impairment has increased as well. Salivary DHEA was correlated with VR total ( R 2 = 0.082, p = 0.01) and attention scores ( R 2 = 0.086, p = 0.009).Ĭonclusion: The VR cognitive test was as effective as the traditional MOCA test in the MCI classification and safe enough for older adults to perform, indicating its potential as a diagnostic tool. The ROC curve analysis also showed a larger area under the curve (AUC) for the VR test (0.765) than for the MOCA test (0.598), and the sensitivity and specificity of the VR program were 0.833 and 0.722, respectively. There was a significant correlation between the MOCA and VR scores in the total and matched subdomain scores. However, the VR total score of the MCI group was significantly lower than that of the normal group ( F = 8.674, p = 0.004). Results: According to the ANCOVA, no significant difference in MOCA scores was found between the normal and MCI groups ( F = 2.36, p = 0.127). An analysis of covariance (ANCOVA), a partial correlation analysis, and receiving operating characteristic (ROC) curve analysis were conducted for statistical analysis. The VR program operates in a situation of caring for a grandchild, and evaluates the memory, attention, visuospatial, and executive functions. Methods: The VR cognitive assessment program and the traditional Montreal Cognitive Assessment (MOCA) test were performed on 12 patients with MCI and 108 healthy older adults. This study aimed to determine the efficacy and usability of a VR cognitive assessment program and salivary DHEA for screening MCI. Meanwhile, dehydroepiandrosterone (DHEA) has been observed at a low concentration in the older adults with dementia or cognitive decline, indicating its potential as a biomarker of MCI. ![]() Virtual reality (VR)-based cognitive assessment program, which is close to the daily life of the older adults, can be suitable screening tools for MCI with ecological validity and accessibility. Objectives: As the significance of the early diagnosis of mild cognitive impairment (MCI) has emerged, it is necessary to develop corresponding screening tools with high ecological validity and feasible biomarkers. 7FNIKorea Co., Ltd., Gwacheon, Gyeonggi-do, Republic of Korea.6Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Gyeonggi-do, Republic of Korea.5Department of Psychiatry, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.4Institute of Behavioral Sciences in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.3Department of Psychiatry, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.2Department of Psychiatry, Ajou University, Suwon, Gyeonggi-do, Republic of Korea.1Research Institute of Minds.AI, Co., Ltd., Seoul, Republic of Korea.Sooah Jang 1 Sun-Woo Choi 1 Sang Joon Son 2 Jooyoung Oh 3,4 Junghee Ha 4,5 Woo Jung Kim 4,6 Hyun Woong Roh 2 Keun You Kim 4,5 San Lee 4,6 Eunjin Jung 4 Woojin Cha 4 Heonjoo Chae 7 Suzi Kang 7 Ji Hye Kwon 1 In-Young Kim 1 Ju-Yeal Lee 1 Hyun Kyung Shin 4 Jin Sun Ryu 1,3 Ryunsup Ahn 1 Chang Hyung Hong 2 Jeong-Ho Seok 1,3,4* ![]()
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